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郑蒙
发布时间:2017年05月18日 08:20    作者:


   郑蒙男,19853月出生,2021欧洲杯买球app校特聘教授。在国际主流期刊Trends in Biotechnology, Advanced Materials, ACS Nano, Biomacromolecules, Molecular Pharmaceutics等上发表论文23篇,H因子16文章总引用次数超900次,其中引用超过100次论文两篇。获国际,中国及日本专利各1项。主持日本学术振兴会(JSPS)外籍特任研究员基金1项,参与了日本大型科研计划FIRST项目及国家自然科学基金2项,目前主持国家自然科学基金1项。指导硕士研究生5人,博士研究生1人,博士后3人,承担研究生课程《纳米生物学》的教学工作;指导5名毕业生完成本科毕业设计;指导本科生在第一届全国大学生生命科学竞赛中获得全国二等奖。

学历背景

2007.09—2012.07 苏州大学,博士 (导师:钟志远教授)

2003.09—2007.07 三峡大学,本科


工作经历

2016.01—现在 2021欧洲杯买球app,生命科学学院,校特聘教授


学术兼职

审稿编辑: Frontiers in Chemistry

审稿人:BiomaterialsBiomacromolecules, Theranostics, Frontiers in Pharmacology, Scientific Reports


发表论文

1. Meng Zheng, Wei Tao, Yan Zou, Omid C. Farokhzad, Bingyang Shi*. Nanotechnology based strategies for siRNA brain delivery for disease therapy. Trends in Biotechnology, 2018, 36: 562-575.

2. Weiming Ruan, Meng Zheng*corresponding author, Yang An, Yuanyuan. Liu, David Lovejoy, Mingcong Hao, Yan Zou, Albert Lee, Shu Yang, Yiqing Lu, Marco Morsch, Roger Chung, Bingyang Shi*. DNA nanoclew templated spherical nucleic acid for siRNA delivery. Chemical Communication, 2018, 54, 3609-3612.

3. Yan Zou, Meng Zheng # (co-first author), Weijing Yang, Fenghua Meng, Kanjiro Miyata, Hyunjin Kim, Kazunori Kataoka, Zhiyuan Zhong. Virus-mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivo. Advanced Materials, 2017, 29: 1703285-1703293

4. Bingyang Shi, Meng Zheng, Wei Tao, Roger Chung, Dayong Jin, Dariush Ghaffari, Omid C. Farokhzad. Challenges in DNA delivery and recent advances in multifunctional polymeric DNA delivery system. Biomacromolecules, 2017, 18 (8), 2231–2246.

5. Meng Zheng, Hyunjin Kim, Shigehito Oosawa, Yu Yi, Kanjiro Miyata, Kazunori Kataoka. Unimer polyion complex self-assembled nanomicelle for systemic delivery of siRNA into solid tumor. Journal of Controlled Release, 2017, 259: e91-e92.

6. Yu Yi, Hyunjin Kim, Peng Mi, Meng Zheng, Hiroyasu Takemoto, Kazuko Toh, Beob Soo Kim, Kotaro Hayashi, Mitsuru Naito, Yu Matsumoto, Kanjiro Miyata, Kazunori Kataoka. Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. Journal of Controlled Release, 2016 244: 247~256.

7. Meng Zheng, Hyun Jin Kim, Hiroyasu Takemoto, Kanjiro Miyata, Kazunori Kataoka. Precisely regulated nanoarchitecture comprised of gold nanotemplate and unimer polyion complex for systemic delivery of siRNA. Journal of Controlled Release, 2015, 213: e75-e76.

8. Weiwei Guo, Meng Zheng, Yinan Zhong, Fenghua Meng, Chao Deng, Zhiyuan Zhong. Poly(ethylene oxide)-graft-methotrexate macromolecular drugs conjugating via aminopteridine ring exhibit potent anticancer activity. Chinese Journal of Chemistry, 2014, 32(1): 57-65.

9. Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Delivery and Translational Research, 2014, 4(1): 50-60.

10. Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi, Peng Mi, Frederico Pittella, R James Christie, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS nano, 2014, 8(9): 8979-8991.

11. Hyun Jin Kim, Kanjiro Miyata, Takahiro Nomoto, Meng Zheng, Ahram Kim, Xueying Liu, Horacio Cabral, R James Christie, Nobuhiro Nishiyama, Kazunori Kataoka. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials, 2014, 35(15): 4548-4556.

12. Wen Hu, Liang Cheng, Lifang Cheng, Meng Zheng, Qifu Lei, Ziyang Hu, Ming Xu, Lipeng Qiu, Dawei Chen. Redox and pH-responsive poly(amidoamine) dendrimer–poly(ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release. Colloids and Surfaces B: Biointerfaces, 2014, 123: 254-263.

13. Wei Chen, Meng Zheng, Fenghua Meng, Ru Cheng, Chao Deng, Jan Feijen, and Zhiyuan Zhong. In situ forming reduction-sensitive degradable nanogels for facile loading and triggered intracellular release of proteins. Biomacromolecules, 2013, 14(4): 1214-1222.

14. Meng Zheng, Zhihong Zhong, Lei Zhou, Fenghua Meng, Rui Peng, and Zhiyuan Zhong. Poly(ethylene oxide) grafted with short polyethylenimine gives DNA polyplexes with superior colloidal stability, low cytotoxicity and potent in vitro gene transfection under serum conditions. Biomacromolecules, 2012, 13(3): 881-888.

15. Meng Zheng, Chunmei Yang, Fenghua Meng, Rui Peng, and Zhiyuan Zhong. pH-sensitive degradable hydrophobe modified 1.8 kDa branched polyethylenimine as “artificial viruses” for safe and efficient intracellular gene transfection. Macromolecular Research, 2012, 20(3): 327-334.

16. Caihong Zhu, Meng Zheng, Fenghua Meng, Frauke Koenig, Nadia Ruthardt, Xiulin Zhu, Zhiyuan Zhong. Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced non-viral gene transfection. Biomacromolecules, 2012, 13(3): 769-778.

17. Yinfeng Du, Wei Chen, Meng Zheng, Fenghua Meng, and Zhiyuan Zhong. pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride. Biomaterials, 2012, 33(29): 7291-7299.

18. Rongran Wei, Liang Cheng, Meng Zheng, Fenghua Meng, Zhiyuan Zhong. Reduction-responsive disassemblable core-crosslinked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anti-cancer drug release. Biomacromolecules, 2012, 13(8): 2429-2438.

19. Shaoke Li, Fenghua Meng, Zhongjuan Wang, Yinan Zhong, Meng Zheng, Haiyan Liu, Zhiyuan Zhong. Biodegradable polymersomes with an ionizable membrane: Facile preparation, superior protein loading, and endosomal pH-responsive protein release. European Journal of Pharmaceutics and Biopharmaceutics, 2012, 82(1): 103-111.

20. Meng Zheng, Yinan Zhong, Fenghua Meng, Rui Peng, Zhiyuan Zhong. Lipoic acid modified low molecular weight polyethylenimine mediates nontoxic and highly potent in vitro gene transfection. Molecular pharmaceutics, 2011, 8(6): 2434-2443.

21. Meng Zheng, Lei Zhou, Ru Cheng, Fenghua Meng, Rui Peng, Zhiyuan Zhong. Poly(ethyleneoxide) grafted with low molecular weight polyethylenimines for non-viral gene transfer. Journal of Controlled Release, 2011, 152: e186-e187.

22. Yuhe Wang#, Meng Zheng# (co-first author), Fenghua Meng, Jing Zhang, Rui Peng, Zhiyuan Zhong. Branched polyethylenimine derivatives with reductively cleavable periphery for safe and efficient in vitro gene transfer. Biomacromolecules, 2011, 12(4): 1032-1040.

23. Zhaozhong Liu#, Meng Zheng# (co-first author), Fenghua Meng, Zhiyuan Zhong. Non-viral gene transfection in vitro using endosomal pH-sensitive reversibly hydrophobilized Polyethylenimine. Biomaterials, 2011, 32(34): 9109-9119.



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