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尹金龙
发布时间:2020年07月08日 15:20    作者:

尹金龙,博士,教授、博士生导师。20112月获韩国国立首尔大学动物生命工学博士学位。2011.3--2015.9在韩国国立癌症中心脑癌研究科从事博士后研究,并于201510月任韩国国立癌症中心癌症科学与政策研究院研究助理教授,20188月受聘于2021欧洲杯买球app特聘教授,20202月获聘河南省特聘教授

联系邮箱:jlyin@henu.edu.cn

主要研究内容: 多形性胶质母细胞瘤(Glioblastoma multiformeGBM)是胶质瘤的一种,是恶性程度及致死率最高的脑部肿瘤。GBM肿瘤细胞具有高浸润性、可大范围转移,不可避免的导致肿瘤复发。而少数具有干细胞特性的胶质瘤干细胞 (GBM stem cells, GSCs)GBM肿瘤形成、发展、浸润侵袭、复发和导致放化疗抗性的根本原因。因此,筛选和鉴定调节胶质瘤干细胞的特异性信号通路及关键基因将为开发针对GBM的有效疗法提供重要线索和依据。具体研究内容包括如下几个方面:

1 胶质瘤干细胞特性维持及信号调节机制研究;

2 胶质瘤干细胞肿瘤微环境的形成及相互作用机制研究;

3 胶质瘤干细胞的靶向治疗研究;

4 患者胶质瘤干细胞的分离、培养,PDX模型的构建及个体化治疗研究。

主持的研究项目:

2021欧洲杯买球app人才特区支持计划(2018-2023

代表性研究成果(*为通讯作者):

1. Yin J*#, Kim SS#, Choi E#, Oh YT#, Lin W, Kime TH, Sa JK, Hong JH, Park SH, Kwon HJ, Jin X, You Y, Kim JH, Kim H, Son J, Lee J, Nam DH, Choi KS, Shi B, Gwak HS, Yoo H, Iavarone A*, Kim JH*, Park JB*. ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. Nature Communications. 2020 11: 2978.

2. Park SM, Seo EH, Bae DH, Kim SS, Kim J, Lin W, Kim KH, Park JB, Kim YS, Yin J*, Kim SY*. PSPH Promotes Lung Cancer Progression through the Dephosphorylation of IRS1 and a Noncanonical L-Serine-Independent Pathway. Molecules and Cells. 2019 42: 604-616.

3. Yin J, Jung JE, Choi SI, Kim SS, Oh YT, Kim TH, Choi E, Lee SJ, Kim H, Kim EO, Lee YS, Chang HJ, Park JY, Kim Y, Yun T, Heo K, Kim YJ, Kim H, Kim YH, Park JB, Choi SW. Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas. Cancer Letters. 2018 414: 181-189.

4. Yin J, Oh YT, Kim JY, Kim SS, Choi E, Kim TH, Hong JH, Chang N, Cho HJ, Sa JK, Kim JC, Kwon HJ, Park S, Lin W, Nakano I, Gwak HS, Yoo H, Lee SH, Lee J, Kim JH, Kim SY, Nam DH, Park MJ, Park JB. Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling. Cancer Research. 2017 77: 4973-4984.

5. Yin J, Kim TH, Park N, Shin D, Choi HI, Cho S, Park JB, Kim JH. TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling. Oncotarget. 2016 7: 79854-79868.

6. Yin J, Park G, Lee JE, Choi EY, Park JY, Kim TH, Park N, Jin X, Jung JE, Shin D, Hong JH, Kim H, Yoo H, Lee SH, Kim YJ, Park JB, Kim JH. DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Brain. 2015 138: 2553-70.

7. Yin J, Park G, Kim TH, Hong JH, Kim YJ, Jin X, Kang S, Jung JE, Kim JY, Yun H, Lee JE, Kim M, Chung J, Kim H, Nakano I, Gwak HS, Yoo H, Yoo BC, Kim JH, Hur EM, Lee J, Lee SH, Park MJ, Park JB. Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells. PLoS Biololgy. 2015 13: e1002152.

8. Yin J, Park G, Lee JE, Park JY, Kim TH, Kim YJ, Lee SH, Yoo H, Kim JH, Park JB. CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression. Oncotarget. 2014 5: 6756-69.

9. Jin X#, Yin J#, Kim SH#, Sohn YW#, Beck S, Lim YC, Nam DH, Choi YJ, Kim H. EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction. Cancer Research. 2011 71: 7125-34 Co-first.

10. Yin J, Kim JK, Moon JH, Beck S, Piao D, Jin X, Kim SH, Lim YC, Nam DH, You S, Kim H, Choi YJ. hMSC-mediated concurrent delivery of endostatin and carboxylesterase to mouse xenografts suppresses glioma initiation and recurrence. Molecular Therapy. 2011 19: 1161-9.

11. Yin J, Jin X, Beck S, Kang DH, Hong Z, Li Z, Jin Y, Zhang Q, Choi YJ, Kim SC, Kim H. In vitro myogenic and adipogenic differentiation model of genetically engineered bovine embryonic fibroblast cell lines. Biotechnology Letters. 2010 32: 195-202.

12.

专利

1. CD97单克隆抗体、其可变区与恒定区序列及应用;201910月;201911038259.4

荣誉奖励

2015.07韩国研奖学-KRF postdoctoral fellow;

2017年度 韩国国立癌症中心最佳员奖


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